The short answer
Erectile dysfunction is persistent difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity. It is common, it is treatable, and it usually has more than one cause — vascular disease, diabetes, medications, neurologic conditions, pelvic surgery or radiation, hormonal factors, stress, sleep and relationship factors can each play a part.
At NovaGenix, treatment starts with a consultation with a physician. We prescribe sildenafil, tadalafil, compounded sublingual formulations and PT-141, and we can test whether low testosterone is contributing if that is a question you want answered.
Why erectile dysfunction is worth evaluating, not just treating
ED can be an early marker of vascular or metabolic disease. The blood vessels in the penis are small and sensitive to impaired endothelial function, so they often show trouble before larger vessels do. In some men, erectile symptoms appear before any other cardiovascular symptom.
That does not mean every case of ED signals heart disease. It does mean that new or persistent ED — especially alongside diabetes, smoking, high blood pressure, obesity or high cholesterol — is worth raising with a physician rather than treating in isolation.
What causes erectile dysfunction?
Physical causes
- Vascular disease — atherosclerosis, hypertension and impaired endothelial function reduce penile blood flow. The most common physical contributor.
- Diabetes — damages both blood vessels and nerves, which is why ED is common and often harder to treat in men with poorly controlled diabetes.
- Obesity and metabolic disease — overlaps with vascular risk, obstructive sleep apnea and hormonal change.
- Neurologic disease — conditions affecting nerve signaling interfere with the physiology of an erection.
- Pelvic surgery or radiation — prostate and other pelvic treatments can affect the nerves and vessels involved.
- Medication effects — several common drug classes contribute (see below).
- Smoking — a well-established, independent ED risk factor.
- Peyronie's disease — scar tissue in the penis can cause curvature, pain and erectile difficulty.
Medications that can contribute to ED
Several classes can affect sexual function, including some antidepressants, certain blood-pressure medications, antiandrogens and opioid medications.
Do not stop a prescription medication on your own. Bring your full list to the consultation. A physician can look at whether the timing of your symptoms lines up with a medication change and whether a different option is worth discussing with the prescriber.
Psychological and relationship factors
Performance anxiety, depression, stress, past trauma and relationship conflict can cause ED or make a physical cause worse. In younger men, intermittent ED with preserved morning or spontaneous erections can suggest a stronger psychogenic component, though no single feature proves the cause on its own.
Psychological and physical causes frequently coexist. Treating one and ignoring the other is a common reason men feel their treatment only half worked.
Can low testosterone cause erectile dysfunction?
It can contribute, but the relationship is widely misunderstood — including by clinics that market testosterone as an ED treatment.
Testosterone has a clearer role in sexual desire than in the mechanics of penile blood flow. Men with confirmed hypogonadism may have reduced libido, fewer spontaneous erections and poorer sexual response, and testosterone therapy may improve those symptoms in selected patients.
But many men with ED have entirely normal testosterone, and many men with low testosterone still need standard ED treatment after their levels are corrected. Testosterone therapy should not be started solely because a man has erectile dysfunction.
This is the question most men actually arrive with, and it is one NovaGenix is well positioned to answer — hormone medicine is what we do. More: low sex drive in men and our testosterone replacement therapy overview.
How treatment starts at NovaGenix
What the consultation covers
Treatment begins with a consultation with a physician — by video or phone, or in person at our Jupiter office. The physician reviews your medical and sexual history, your current medications, and your cardiovascular and metabolic risk factors, then discusses which treatment fits your situation.
No prescription issues from an online form alone. You talk to a doctor. That is the difference between this and the questionnaire-and-checkout services, and it is why the medication you leave with is matched to your history rather than to whatever the site sells.
Is blood work required?
No. Most ED treatment does not require lab work, and we do not gate treatment behind it.
What we do offer is the option. Many men with ED want to know whether testosterone is playing a role, and because NovaGenix is a hormone clinic, that is a question we can actually pursue rather than deflect. Dr. Mackey advises on which labs are worth running, case by case, if you want that answered. If you are also considering hormone therapy, our guide to the blood tests required before starting TRT covers that panel.
Erectile dysfunction treatment options at NovaGenix
First-line: sildenafil and tadalafil
Oral phosphodiesterase type 5 inhibitors — sildenafil and tadalafil — are the first-line treatment for most men with ED. They improve the erectile response to sexual stimulation by enhancing nitric-oxide signaling and blood flow. They do not create an erection on their own; sexual stimulation is still required.
PDE5 inhibitors such as sildenafil and tadalafil can cause a dangerous blood-pressure drop when combined with nitrates, recreational nitrites (“poppers”) or riociguat. Do not combine them. The prescriber must review all medications and supplements. Caution is also warranted in certain cardiovascular conditions. This is a category where your medical history genuinely matters, which is why a physician reviews it.
We prescribe both: prescription sildenafil and prescription tadalafil.
Sildenafil vs. tadalafil
| Sildenafil | Tadalafil | |
|---|---|---|
| Common brand | Viagra | Cialis |
| Duration | Shorter acting | Longer acting |
| Typical use | On demand | On demand, or low-dose daily |
| Food effect | Absorption affected by a heavy or high-fat meal | Less affected by food |
| Planning | Requires timing around activity | Allows more spontaneity |
The better medication is the one that is safe, effective and practical for you — not the strongest advertised dose. Response varies between individuals, and a man who does poorly on one PDE5 inhibitor may do well on the other.
Compounded sublingual ED medication
We offer compounded sublingual formulations prepared by a licensed compounding pharmacy — both single-agent and a sildenafil/tadalafil combination, depending on what suits the patient.
Compounded medications are not FDA-approved products. Compounding allows a formulation or route that is not commercially available, which can matter for men who have difficulty with standard tablets or prefer sublingual administration. It is not evidence that a compounded product outperforms a brand or generic PDE5 inhibitor, and we do not claim that it does. Whether a compounded formulation is appropriate for you is decided during your consultation.
PT-141 (bremelanotide)
PT-141 is a melanocortin-receptor agonist given by subcutaneous injection. Unlike PDE5 inhibitors, which act on blood flow, PT-141 acts centrally on pathways involved in sexual desire — which makes it a different tool for a different problem, and sometimes a complementary one.
PT-141 is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. Its use in men is off-label, and the formulation we prescribe is compounded and therefore not an FDA-approved product. Off-label prescribing is legal and common in medicine, but you should know that is what it is. More detail on our PT-141 page.
Where testosterone therapy fits
Testosterone therapy may improve sexual symptoms in men with confirmed testosterone deficiency, particularly when low libido is part of the picture. In men who remain symptomatic after their levels are corrected, standard ED treatments are often still needed — the two are not interchangeable.
We do not start testosterone therapy because a man has ED. We start it when testing confirms hypogonadism and symptoms match.
Treatments we refer out
Being straight about what we do not do is part of being useful. NovaGenix is a physician-led hormone and men's health practice, not a urology surgical practice. The following are established, evidence-based ED treatments that we do not provide — if one of them is what you need, we will tell you and point you to a urologist.
Injection therapy, vacuum devices and implants
- Intracavernosal injection therapy — medication injected into the penis, acting directly on smooth muscle and blood flow. It can be highly effective, including in some men who do not respond to oral medication. It is not risk-free: risks include pain, bruising, fibrosis and priapism, and dose titration should be supervised. Referral.
- Vacuum erection devices — negative pressure draws blood into the penis, usually with a constriction ring placed afterward. Non-systemic and useful when medications are contraindicated. Referral.
- Penile implants — surgical treatment generally reserved for men with persistent ED who do not respond to or cannot tolerate less invasive options. Satisfaction is high in appropriately selected patients, but it is surgery with real risks. Referral to urology.
What about shockwave therapy?
Low-intensity shockwave therapy has been studied for vasculogenic ED, but protocols, devices and evidence quality vary considerably between studies, and long-term comparative data are limited.
NovaGenix does not offer shockwave therapy. We are not comfortable selling a treatment marketed as a cure when the evidence does not yet support that claim. If you are considering it elsewhere, understand that it is not equivalent to established first-line treatment.
What if the medication doesn't work?
Failure of one PDE5 inhibitor does not mean oral therapy has failed. Before concluding that, the physician will review:
- Whether the diagnosis is right, and whether an untreated contributor — diabetes, a medication, sleep apnea, hormonal deficiency — is still in play
- Dose — many men are undertreated
- Timing relative to activity, and whether food is interfering with absorption
- Whether there has been adequate sexual stimulation; the medication does not work without it
- Whether enough separate attempts have been made, since response often improves over several tries
- Whether the other PDE5 inhibitor, or a compounded sublingual formulation, is worth trying
A meaningful share of "non-responders" are men who never had a fair trial of first-line treatment. If oral therapy genuinely fails, the next options are injection therapy, vacuum devices or urologic treatment — and we will refer you.
Lifestyle changes that support erectile function
Improving vascular health improves erectile function in some men. The measures that matter most:
- Stopping smoking
- Regular aerobic exercise
- Weight reduction where appropriate
- Better diabetes control
- Limiting excessive alcohol
- Treating obstructive sleep apnea
These support overall health and work alongside medical treatment. Unlike a prescription, they address the vascular problem underneath.
When erectile dysfunction needs urgent care
An erection lasting four hours or more requires emergency care, even if it is not painful. If chest pain occurs after an ED medicine, seek emergency care and tell the team which medicine was taken and when; do not take a nitrate yourself. Sudden vision or hearing loss requires immediate medical attention. Prolonged ischemia can permanently injure penile tissue. Go to an emergency room — do not wait for a clinic appointment.
Sudden ED accompanied by chest pain, neurologic symptoms, or other acute illness also needs urgent evaluation.
Avoid unregulated ED products
Be cautious with "herbal Viagra," gas-station pills and unlicensed online sellers. The FDA has repeatedly identified sexual-enhancement supplements contaminated with undeclared prescription drug ingredients or chemical analogues of them.
These products are dangerous precisely because the label does not tell you what is in them — which matters enormously if you take nitrates or other cardiovascular medications. Prescription ED treatment should come from a licensed clinician and a licensed pharmacy.
Serving Jupiter and northern Palm Beach County
NovaGenix Health & Wellness is at 609 N Hepburn Ave Ste 106, Jupiter, FL 33458, off Indiantown Road just west of US-1. We have provided physician-led men's health care here since 2016.
We see patients from Jupiter, Palm Beach Gardens, Tequesta, Juno Beach, North Palm Beach, Hobe Sound, Palm City and throughout northern Palm Beach and Martin counties. Most patients reach the office in under 20 minutes from Palm Beach Gardens or Tequesta. Consultations are also available by video or phone.
Hours: Monday–Friday, 9:00 AM – 5:00 PM Phone:561-277-8260
Frequently asked questions about erectile dysfunction
Is ED a normal part of aging?
ED becomes more common with age, but persistent erectile dysfunction should not be dismissed as inevitable aging. Treatable vascular, metabolic, medication and hormonal factors are often present, and finding them matters for more than sexual function.
Does low testosterone always cause ED?
No. Low testosterone can contribute to sexual symptoms, particularly reduced desire, but most erectile dysfunction has a significant vascular, neurologic, medication or psychological component. Many men with ED have normal testosterone levels.
Do I need blood work before ED treatment?
No. Most ED treatment does not require lab work. Because NovaGenix is a hormone clinic, we can test whether low testosterone is contributing if you want that question answered, and Dr. Mackey advises on which labs are worth running case by case — but it is optional, not a requirement for treatment.
What is the best ED medication?
There is no universal best medication. Sildenafil and tadalafil are the common first-line options, and the right choice depends on your health history, timing preferences, side effects, drug interactions and individual response. The best medication is the one that is safe and effective for you.
What if Viagra or Cialis doesn't work?
The diagnosis, dose, timing and how the medication is being used should all be reviewed first, because many apparent non-responders never had an adequate trial. A different formulation, including a compounded sublingual option, may also be worth trying. If oral medication genuinely fails, injection therapy, vacuum devices and urologic treatments are established options, and we will refer you.
Can erectile dysfunction be reversed?
Sometimes. ED driven by smoking, obesity, poor diabetes control, medication effects or psychological factors can improve substantially when those contributors are addressed. Other causes require ongoing treatment.
Do I have to come into the office?
No. New patients can start with a video or phone consultation with a physician, and our Jupiter office is available if you prefer to be seen in person. What we do not do is issue a prescription from an online form without a physician consultation.
What is premature ejaculation, and do you treat it?
Premature ejaculation is ejaculation that occurs sooner than a man or his partner would like, often within a few minutes of penetration. It is a separate condition from erectile dysfunction, though the two can occur together and anxiety about one can worsen the other. We evaluate and treat both.
Talk to a physician about erectile dysfunction
NovaGenix reviews sexual symptoms, current medications, cardiovascular and metabolic risk factors, hormone testing where you want it, and the treatment options that fit your situation — under the direction of Dr. Timothy W. Mackey, D.O., our Medical Director. Learn more about NovaGenix Health & Wellness.
Call 561-277-8260 · Text NovaGenix · Schedule a consultation
Medical references
- American Urological Association — Erectile Dysfunction Guideline
- NIDDK — Erectile Dysfunction
- FDA — Tainted Sexual Enhancement Products
This article is educational and does not replace individualized diagnosis or treatment. A prolonged painful erection, or acute cardiovascular or neurologic symptoms, require urgent medical care.


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