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Estrogen Ballance in Men on TRT: Where Should My Estradiol Be?

We often get asked by male patients about estrogen and the importance that it plays in hormone replacement therapy. Many patients have misconceptions about estrogen and where their levels should be. It’s of the upmost importance that a male’s estrogen levels remain balanced while on testosterone replacement therapy. The importance of seeking help from trained experienced medical professionals is extremely important for patients on TRT and the value of getting proper blood tests performed.

There are many studies that have been published with data showing that when estrogen levels become out of balance there is an increased risk of many chronic diseases for aging males. Also remarkable are studies that have been able to link elevated estrogen levels to atherosclerosis. Men with elevated estrogen levels will double their risk of stroke and had statistically have significantly higher occurrences of coronary artery disease as well. It has also been shown that men with benign prostate enlargement or prostate cancer had elevated blood estrogen levels often in conjunction with low free testosterone levels. On the other side of the fence, men with abnormally low estrogen levels are predisposed to having fragile bones which often fracture and are at a higher risk of osteoporosis. Most men do not know what their estrogen levels actually are and this is a large concern considering the effect that it has on the overall health and wellness of men and the increase in age related diseases occurring as a result.

The Journal of the American medical Association or JAMA recently published a new study which measured the blood estradiol (a dominant form of estrogen in men) in 501 men with chronic heart failure. Comparing the estrogen levels across the population of test subjects, men in the lowest quartile of estrogen levels (the bottom 25%) were 317% more likely going to die during a follow up appointment within three years of having started this research study. These patients had estrogen levels under 12.9 pg/mL. Men in the highest quartile (top 25%) were 133% more likely to die with estradiol levels of 37.4 and above, whereas the men who were in the middle range of 21.80 to 30.11 pg/mL had the fewest deaths reported. At NovaGenix our goal is to keep your estrogen levels between 20 and 30 for this exact reason. To optimize your overall health. In another study, 3014 men between the ages of 69 and80 had their serum testosterone and estradiol levels measured with an average follow up period of 4.5 years. Men who suffered from low testosterone had a 65% higher all-cause mortality rate while the men with low estradiol levels suffered 54% more deaths then those with optimal levels.
In the male body, aromatase, an enzyme turns testosterone into estradiol. Aging males often have too much of this enzyme activity that may cause they’re testosterone to be more easily synthesized into excess estrogen. Not only does this take away from the body is testosterone levels but will also increase estrogen into ranges that are sub optimal and leave a patient more likely to suffer from some of the aforementioned unwanted health conditions.

Patients on testosterone replacement therapy it is important to minimalize excess aromatase. If need be, we may prescribe to our patients an aromatase inhibitor such as Arimidex or Anastrozole. By properly suppressing estradiol levels into safe ranges between 20 and 30 pg/mL, you will increase testosterone levels and optimize hormones more effectively.
For more information on testosterone replacement therapy and the importance of estrogen balance for man on TRT, please visit NovaGenix.org and call 561-277-8260 to schedule an appointment to speak with our doctor today. Swing by our office at 609 N. Hepburn Ave. Suite 106 Jupiter, FL 33458 and let us know how we can help you today.


The information mentioned is not intended as medical treatment, but information only. We advise to seek the advice of a trained and licensed medical professional to perform a proper evaluation.

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